 |
熊燕 教授，博士生导师。2007年毕业于四川大学有机化学专业，获博士学位，师从冯小明教授，从事不对称催化合成研究。2008年爱尔兰都柏林大学CSCB研究中心做博士后，从事高价碘化学与过渡金属催化去对称化研究，爱尔兰政府IRCSET学者，导师Dr. Hasim Ibrahim。 2009年回国，公司任教，从事有机化学的教学科研工作。2014年北京大学做访问学者，导师刘忠范教授，主要从事新型骨架构建的碳材料研究。曾前往法国、德国、韩国等进行学术交流访问。 主持国家自然科学基金面上项目、地区基金、国际合作项目，教育部留学回国人员启动基金、博士点基金，重庆市科技支撑示范工程项目，重庆市自然科学基金项目，国家重点实验室开放课题、企业课题等40余项。指导培养博士后1名、博士生7名（国际职工1名），硕士生25名（国际职工1名）。发表学术论文60余篇，最高单篇SCI他引175次，获授权专利5项。 |
联系方式
理科楼LC715室。Email：xiong@cqu.edu.cn
研究方向
1. 化学工程与技术。化工新材料，新型骨架碳材料的设计、制备和表征；金属离子与农药残留检测的电化学传感器制备；有机化工工艺路线的设计与开发。
2. 有机化学。不对称合成，从事具有生物活性的手性农药、医药及其中间体的合成。
3. 电化学。利用电催化过程，实现功能材料及有机功能分子的转化。
近年主持科研项目
[1] 国家自然科学基金：苯酚去芳构化中手性远程控制策略研究，主持，时间：2022-2025.
[2] 国家自然科学基金：手性甜菜碱类双功能基催化剂的设计合成及其在不对称亲电氰化反应中的应用研究，主持，时间：2014-2017。
[3] 国家自然科学基金：Organocatalysis: a Green Technology to Convert Simple Feed-Stocks into Molecular Architectures of Biological Interest，主持，时间：2014。
[4] 教育部留学回国人员科研启动基金：具有C2对称手性碘化合物的设计合成及其在不对称催化氧化反应中的应用研究，主持，时间：2012-2014。
[5] 教育部博士点新教师基金：手性双功能基催化硝基烯烃的不对称氢氰化反应研究，主持，时间：2013-2015。
[6] 重庆市自然科学基金：手性碘代芳烃催化不对称氰化反应研究，主持，时间：2016-2018。
[7] 重庆市科技支撑示范工程项目：重庆化工新材料产业示范工程协同管理创新与应用研究/共性技术攻关，主持，时间：2013-2015。
[8] 重庆市自然科学基金：手性碘催化剂设计：一种有效的构建具有生物活性手性亚砜的技术，主持，时间：2013-2015。
[9] 中法国际合作交流项目：L’Organocatalyse : une Technologie Verte pour la Valorisation des Phénols en Briques Moléculaires d’Intérêt Thérapeutique，主持，时间：2012-2013。
[10] 企业合作项目。
代表性学术论文
[1] Liangzhen Hu,* Tianyong Gao, Qingfu Deng, Yan Xiong,* Organoiodine-Induced Hydroxylation as Well as Enantioselective Alkoxylation/Hydroxylation of Allylic Alcohols via 1,2-Aryl Migration, Tetrahedron 2021, 95, 132334.
[2] Yangang Feng, Chenglin Yang, Qingfu Deng, Ruimei Xiong, Xiaohui Zhang, Yan Xiong,* Synthesis of Antitricyclic Morpholine Derivatives through Iodine(III)-Mediated Intramolecular Umpolung Cycloaddition of Olefins, J. Org. Chem. 2020, 85, 4500-4506.
[3] Qingfu Deng, Wen Xia, Muhamad Ijaz Hussain, Xiaohui Zhang, Wen Hu, Yan Xiong,* Synthesis of Polycyclic Cyclohexadienone through Alkoxy-Oxylactonization and Dearomatization of 3′-Hydroxy-[1,1′-biphenyl]-2-carboxylic Acids Promoted by Hypervalent Iodine, J. Org. Chem. 2020, 85, 3125-3133.
[4] Youcai Ma, Ruimei Xiong, Yangyang Feng, Xiaohui Zhang, Yan Xiong,* Synthesis of 1,2-disubstituted benzimidazoles through DDQ-oxidized intramolecular dehydrogenative coupling of N,N'-dialkyl ophenylenediamines, Tetrahedron 2020, 76, 131474.
[5] Liangzhen Hu, Qingfu Deng, Yong Zhou, Xiaohui Zhang, Yan Xiong,* Cu2O-Catalyzed Phosphonyl Difluoromethylation of Allylic Alcohols through a Radical 1,2-Aryl Migration, Tetrahedron 2020, 76, 130949.
[6] Ruimei Xiong, Muhammad Ijaz Hussain, Qing Liu, Wen Xia, Yan Xiong,* Cross Dehydrogenative Coupling Strategy for Allylation of Benzylanilines Promoted by DDQ, Tetrahedron 2020, 76, 130798.
[7] Jingyuan Zhou, Ziqian Xie, Rong Liu, Xin Gao, Jiaqiang Li, Yan Xiong, Lianming Tong, Jin Zhang,* Zhongfan Liu,* Synthesis of Ultrathin Graphdiyne Film Using a Surface Template, ACS Appl. Mater. Interfaces 2019, 11, 2632−2637.
[8] Jiaqiang Li, Yan Xiong, Ziqian Xie, Xin Gao, Jingyuan Zhou, Chen Yin, Lianming Tong, Changguo Chen,* Zhongfan Liu,* Jin Zhang,* Template Synthesis of an Ultrathin β‑Graphdiyne-Like Film Using the Eglinton Coupling Reaction, ACS Appl. Mater. Interfaces 2019, 11, 2734−2739.
[9] Liangzhen Hu, Muhamad Ijaz Hussain, Qingfu Deng, Qing Liu, Yangyang Feng, Xiaohui Zhang, Yan Xiong,* I2/Li2CO3-Promoted Cyanation of Diarylalcohols through a Dual Activation Process, Tetrahedron 2019, 75, 308-314.
[10] Muhamad Ijaz Hussain, Yangyang Feng, Liangzhen Hu, Qingfu Deng, Xiaohui Zhang, Yan Xiong,* Copper-Catalyzed Oxidative Difunctionalization of Terminal Unactivated Alkenes, J. Org. Chem. 2018, 83, 7852-7859.
[11] Qing Liu, Shuchen Yu, Liangzhen Hu, Muhamad Ijaz Hussain, Xiaohui Zhang, Yan Xiong,* Cross-Dehydrogenative Coupling Strategy for Phosphonation and Cyanation of Secondary N-alkyl Anilines by Employing 2,3-Dichloro-5,6-dicyanobenzoquinone, Tetrahedron 2018, 74, 7209-7217.
[12] Ruojuan Liu, Junzheng Wang, Wen Hu, Xiaohui Zhang, Yan Xiong,* α-Sulfonyloxylation of 1,3-Dicarbonyl Compounds Utilizing Hypervalent Iodine(III) Reagent: Construction of Quaternary Carbon Center, Synthetic Commun. 2018, 48, 1957-1965.
[13] Yangyang Feng, Muhamad Ijaz Hussain, Xiaohui Zhang, Jian Shi, Yan Xiong,* Aerobic Intramolecular Aminothiocyanation of Unactivated Alkenes Promoted by in situ Generated Iodine Thiocyanate, Tetrahedron 2018, 74, 2669-2676.
[14] Mingming Huang, Qingfu Deng, Qin Gao, Jian Shi, Xiaohui Zhang, Yan Xiong,* Iron-Sulfate-Catalyzed Direct Dehydrogenative Coupling Cyanation of Secondary Phenylamines, Asian J. Org. Chem. 2018, 7, 404-410.
[15] Jing Xu, Jiaqiang Li, Qiaoling Yang, Yan Xiong, Changguo Chen* In-situ Synthesis of MnO2@Graphdiyne Oxides Nanocomposite with Enhanced Performance of Supercapacitors, Electrochimica Acta 2017, 251, 672–680.
[16] Hang Shen, Qingfu Deng, Ruojuan Liu, Yangyang Feng, Yan Xiong* Hypervalent Iodine-Promoted Annulative Aminocyanation of Unactivated Alkenes. Org. Chem. Front. 2017, 4, 1806-1811. (IF = 5.0)
[17] Congke Zheng, Xiaohui Zhang, Muhammad Ijaz Hussain, Mingming Huang, Qing Liu, Yan Xiong,* Xiangming Zhu,*One-pot Dichlorinative Deamidation of Primary β-Ketoamides. Tetrahedron Lett. 2017, 58, 574-577.
[18] Jiaqiang Li, Ziqian Xie, Yan Xiong, Zhenzhu Li, Qunxing Huang, Shuqing Zhang, Jingyuan Zhou, Rong Liu, Xin Gao, Changguo Chen, Lianming Tong*, Jin Zhang*, Zhongfan Liu,* Architecture of β-Graphdiyne Contained Thin Film Using Modified Glaser-Hay Coupling Reaction for Enhanced Photocatalytic Property of TiO2. Adv.Mater. 2017, 29, 1700421. (IF = 30.8)
[19] Liangzhen Hu, Jing Pan, Xiaohui Zhang, Wen Hu, Yan Xiong,* Xiangming Zhu, Synthesis of N, O π-Conjugated Boron Complexes and the Reactivity of Suzuki Cross-Coupling. Tetrahedron 2017, 73, 223-229.
[20] Qing Liu, Xiaohui Zhang,* Yang He, Muhammad Ijaz Hussain, Wen Hu, Yan Xiong,* Xiangming Zhu, Oxidative Rearrangement Strategy for Synthesis of 2, 4, 5-Trisubstituted Oxazoles Utilizing Hypervalent Iodine Reagent. Tetrahedron 2016, 72, 5749-5753.
[21] Yangyang Feng, Ruofeng Huang, Liangzhen Hu, Vincent Coeffard,* Yan Xiong,* Enantioselective α-Oxytosylation of 1,3-Dicarbonyl Compounds Catalyzed by Chiral C2-Symmetric Iodoarenes. Synthesis 2016, 48, 2637-2644.
[22] Mingming Huang, Liangzhen Hu, Hang Shen, Qing Liu, Muhammad Ijaz Hussain, Jing Pan, Yan Xiong,* Metal-Free Strategy for Sulfination of Alcohols with Sodium Sulfinates: An Unexpected Access. Green Chem. 2016, 18, 1874-1879. (IF = 10.2)
[23] Hang Shen, Liangzhen Hu, Qing Liu, Muhammad Ijaz Hussain, Jing Pan, Mingming Huang, Yan Xiong,* Iron-Catalysed Sequential Reaction towards alpha-Aminonitriles from Secondary Amines, Primary Alcohols and Trimethylsilyl Cyanide. Chem. Commun. 2016, 52, 2776-2779. (IF = 6.3)
[24] Yang Li, Ping Deng, Youmao Zeng, Yan Xiong, Hui Zhou,* anti-Selective Asymmetric Henry Reaction Catalyzed by a Heterobimetallic Cu–Sm–Aminophenol Sulfonamide Complex. Org. Lett. 2016, 18, 1578-1581. (IF = 6.6)
[25] Youmao Zeng, Ping Deng, Shixiong Zhang, Hong Yan, Guojuan Liang, Yan Xiong, Hui Zhou,* An Ni–PyBisulidine Complex for the Asymmetric Hydrophosphonylation of Aldehydes. Org. Biomol. Chem. 2016, 14, 9221-9224.
[26] Hang Shen, Xiaohui Zhang, Qing Liu, Jing Pan, Wen Hu, Yan Xiong,* Xiangming Zhu, Direct Oxidative Cyanation of Tertiary Amines Promoted by in situ Generated Hypervalent Iodine(III)-CN Intermediate. Tetrahedron Lett. 2015, 56, 5628-5631.
[27] Jiaqiang Li, Hang Shen, Qing Liu, Mingming Huang, Congke Zheng, Jing Pan, Yan Xiong,* Changguo Chen,*BF3·OEt2-catalyzed Etherification of Alcohols: a Metal-free Pathway to Diphenylmethyl Ethers. Adv. Synth. Catal. 2015, 357, 3115-3120. (IF = 5.6)
[28] Hang Shen, Jiaqiang Li, Qing Liu, Jing Pan, Ruofeng Huang, Yan Xiong,* Umpolung Strategy for Synthesis of β-Ketonitriles through Hypervalent Iodine-Promoted Cyanation of Silyl Enol Ethers. J. Org. Chem. 2015, 80, 7212-7218. (IF = 4.8)
[29] Jiaqiang Li, Qing Liu, Hang Shen, Ruofeng Huang, Xiaohui Zhang Yan Xiong,* Changguo Chen,* Ethers as Hydrogen Sources in BF3·OEt2 Promoted Reduction of Diphenylmethyl Alcohols, Ethers and Esters to Hydrocarbons. RSC Adv. 2015, 4, 85291-85295.
[30] Jing Pan, Jiaqiang Li, Ruofeng Huang, Xiaohui Zhang, Hang Shen, Yan Xiong,* Xiangming Zhu, Extension Studies on Iron(III)-Promoted Free Radical Oxidation of Anilines. Tetrahedron 2015, 71, 5341-5346.
[31] Jing Pan, Jiaqiang Li, Ruofeng Huang, Xiaohui Zhang, Hang Shen, Xuege Ling, Yan Xiong,* Xiangming Zhu, Direct Metal-Free N-Benzylaiton of Sulfonamides with Benzyl Alcohols Promoted by Employing BF3·Et2O. Synthesis 2015, 47, 1101-1108.
[32] Xiaohui Zhang, Ruofeng Huang, Jérôme Marrot, Vincent Coeffard,* Yan Xiong,*Hypervalent Iodine-Mediated Synthesis of Benzoxazoles and Benzimidazoles via an Oxidative Rearrangement. Tetrahedron 2015, 71, 700-708.
[33] Ruofeng Huang, Xuege Ling, Xiaohui Zhang, Jing Pan, Chao He, Yan Xiong,* Benzylation of Arenes with Benzyl Halides Synergistically Promoted by in situ Generated Superacid Boron Trifluoride Monohydrate and Tetrahaloboric Acid. Tetrahedron 2015, 71, 1540-1546.
[34] Hang Ma, Yang He, Ruofeng Huang, Xiaohui Zhang, Jing Pan, Jiaqiang Li, Chao He, Xuege Ling, Xuanlun Wang,Yan Xiong,* Nucleophilic Imidoesterification of Dicarbonyl Compounds with Cyanatobenzenes through C-C Bond Formation. Chin. Chem. Lett. 2014, 25, 1327-1330.
[35] Shuting Zhang, Xiaohui Zhang, Xuege Ling, Chao He, Ruofeng Huang, Jing Pan, Jiaqiang Li, Yan Xiong,* Superacid BF3-H2O Promoted Benzylation of Arenes with Benzyl Alcohols and Acetates Initiated by Trace Water. RSC Adv. 2014, 4, 30768-30774.
[36] Yajun Liu, Ping Deng, Xiangyang Li, Yan Xiong, Hui Zhou,* Asymmetric Henry Reaction Catalyzed by a Chiral Dinuclear Nickel Complex. Synlett 2014, 25, 1735-1738.
[37] Chao He, Xiaohui Zhang, Ruofeng Huang, Jing Pan, Jiaqiang Li, Xuege Ling, Yan Xiong,* Xiangming Zhu, Synthesis of Structurally Diverse Diarylketones through the Diarylmethyl sp3 C-H Oxidation. Tetrahedron Lett. 2014, 55, 4458-4462.
[38] Yu Li, Yan Xiong,* Xueming Li,* Xuege Ling, Ruofeng Huang, Xiaohui Zhang, Jianchun Yang, Benzylation of Arenes with Benzyl Ethers Promoted by in situ Prepared Superacid BF3-H2O. Green Chem. 2014, 16, 2976-2981. (IF = 10.2)
[39] Zhiyong Wang*, Xiaoxiao Xing, Liun Xue, Yan Xiong, Ling Fang*. Iron(III) Chloride Catalyzed Formation of Aryl Hydrazides from Electron-Rich Arenes and Azodicarboxylates, Synthesis 2014, 757-760.
[40] Xiafei Xu, Yan Xiong,* Xuege Ling, Ximi Xie, Jie Yuan, Shuting Zhang, Zhongrong Song,* A Practical Synthesis of Bis(indolyl)methanes Catalyzed by BF3·OEt2. Chin. Chem. Lett. 2014, 25, 406-410.
[41] Xuege Ling, Yan Xiong,* Ruofeng Huang, Xiaohui Zhang, Shuting Zhang, Changguo Chen,* Synthesis of Benzidine Derivatives via FeCl3·6H2O-Promoted Oxidative Coupling of Anilines. J. Org. Chem. 2013, 78, 5218-5226. (IF = 4.8)
[42] Ramulu Akula, Yan Xiong, Hasim Ibrahim,* Electrophilic α-Cyanation of 1,3-Dicarbonyl Compounds. RSC Adv. 2013, 3, 10731-10735.
[43] Xue-Ge Ling, Yan Xiong,* Shu-Ting Zhang, Ruo-Feng Huang, Xiao-Hui Zhang, Effective Synthesis of Benzyl Halides Triggered by in situ Prepared Hypervalent Halides. Chin. Chem. Lett. 2013, 24, 45-48.
[44] Qixiang Guo,* Wei Wen, Lina Fu, Shunen Zhang, Lanxi Zhang, Yuwan Liu, Biao Xu, Yan Xiong, Organocatalytic Aldol Reaction of Indole-3-Carbaldehydes with Ketones: Synthesis of Chiral 3-Substituted Indoles. Tetrahedron Lett. 2013, 54, 4653-4654.
[45] Yan Xiong,* Shuting zhang, Xuege Ling, Xu Zhang, Jinyue Wang, Theoretical Investigation on Identical Anionic Halide-Exchange SN2 Reaction Processes on N-Haloammonium Cation NH3X+ (X = F, Cl, Br, and I). Int. J. Quantum Chem. 2012, 112, 2475-2481.
[46] Xu Zhang, Yan Xiong,* Shuting Zhang,Xuege Ling, Jinyue Wang, Changguo Chen,* Aldol Condensations of Aldehydes and Ketones Catalyzed by Primary Amine on Water. Asian J. Chem. 2012, 24, 751-755.
[47] Yan Xiong,* Xueqiang Zhang, Significant Heterogeneous Carbonate Salt Catalyzed Acetylation of Alcohols via a Transesterification Process with Carbonate Salt-Activated Alcohol 1H NMR Evidence. Chin. J. Chem. 2011, 29, 1143-1148.
[48] Shiyuan Zheng, Yan Xiong,* Jinyue Wang, Theoretical Studies on Identity SN2 Reactions of Lithium Halide and Methyl Halide: A Microhydration Model. J. Mol. Model. 2010, 16, 1931-1937.
[49] Fei Wang, Xiaohua Liu, Xin Cui, Yan Xiong, Xin Zhou, Xiaoming Feng,* Asymmetric Hydrophosphonylation of α-Ketoesters Catalyzed by Cinchona-derived Thiourea Organocatalyst. Chem. Eur. J. 2009, 15, 589-592.
[50] Shiyuan Zheng, Jinyue Wang and Yan Xiong,* Theoretical Investigation on Isomerization of Et2AlCN to Et2AlNC and Cyanation of Aldimine. J. Mol. Struct.: THEOCHEM 2008, 869, 83-88.
[51] Yan Xiong, Fei Wang, Shunxi Dong, Xiaohua Liu, Xiaoming Feng,* Asymmetric Bisprolinamide-Catalyzed Cross-Aldol of Aldehydes. Synlett 2008, 73-75.
[52] Yan Xiong, Yuehong Wen, Fei Wang, Bo Gao, Xiao Huang, Xiaohua Liu, Xiaoming Feng,* A Chiral Functionalized Salt-Catalyzed Asymmetric Michael Addition of Ketones to Nitroolefins. Adv. Synth. Catal. 2007, 349, 2156-2166.
[53] Yan Xiong, Fei Wang, Xiao Huang, Yuehong Wen, Xiaoming Feng,* A New Copper(I)-Tetrahydrosalen-Catalyzed Asymmetric Henry Reaction and Its Extension to Synthesis of (S)-Norphenylephrine. Chem. Eur. J. 2007, 13, 829-833.
[54] Yuehong Wen, Yan Xiong, Lu Chang, Jinglun Huang, Xiaohua Liu, Xiaoming Feng,* Chiral Bisformamide as an Effective Asymmetric Organocatalyst for One-Pot Three-Component Strecker Reaction. J. Org. Chem. 2007, 72, 7715-7719.
[55] Fei Wang, Yan Xiong, Xiaohua Liu, Xiaoming Feng,* Asymmetric Direct Aldol Reaction of α-Keto Esters and Acetone Catalyzed by Organocatalyst. Adv. Synth. Catal. 2007, 349, 2665-2668.
[56] Yi Ren,* Jinggang Gai, Yan Xiong, Kuo-Hsing Lee, San-Yan Chu, Theoretical Study on the Identity Ion Pair SN2 Reactions of LiX with CH3SX (X = Cl, Br, and I): Structure, Mechanism, and Potential Energy Surface. J. Phys. Chem. A 2007, 111, 6615-6621.
[57] Yan Xiong, Xiao Huang, Shaohua Gou, Jinglun Huang, Yuehong Wen, Xiaoming Feng,* Enantioselective Cyanosilylation of Ketones Catalyzed by a Nitrogen-Containing Bifunctional Catalyst. Adv. Synth. Catal. 2006, 348, 538-544.
[58] Shaohua Gou, Xiaohong Chen, Yan Xiong, Xiaoming Feng,* Highly Enantioselective Cyanation of Aldehydes Catalyzed by A Multicomponent Titanium Complex. J. Org. Chem. 2006, 71, 5732-5736.
[59] Yuehong Wen, Xiao Huang, Jinglun Huang, Yan Xiong, Bo Qin, Xiaoming Feng,* Asymmetric Cyanosilylation of Aldehydes Catalyzed by Novel Organocatalysts. Synlett 2005, 16, 2445-2448.
[60] Yan Xiong, Hua-jie Zhu, Yi Ren,* A Theoretical Study of The Gas-phase Ion Pair SN2 Reactions of Lithium Halide and Methyl Halide with Inversion and Retention Mechanisms. J. Mol. Struct.: THEOCHEM 2003, 664-665, 279–289.
